Research progress of anti-gynoecological tumors effect of shikonin and its derivatives / 中草药

ABSTRACT

Shikonin is a natural naphthoquinone compound extracted from the traditional Chinese medicine-Lithospermum, and it has anti-inflammatory, antioxidant, anti-tumor, wound healing, and other effects. In recent years, the antitumor effects of shikonin and its derivatives have been studied extensively. Numerous studies in vitro and in vivo showed that shikonin and its derivatives can effectively inhibit the initiation and development of breast cancer, cervical cancer and other gynecological malignancies, the research progress of shikonin in the field of anti-gynecological tumors in recent years was reviewed from the aspects of blocking cell cycle, promoting tumor cell apoptosis, inhibiting cancer cell metastasis and invasion, inducing autophagy and necrosis, etc. It provides a reference for the clinical research of shikonin compounds in gynecological tumors.