Studies of sesquiterpenes from Myrrha / 中草药

ABSTRACT

Objective: To study the chemical constituents from Myrrha. Methods: The compounds were isolated and purified by column chromatography over silica gel, Sephadex LH-20, RP-ODS and preparative RP-HPLC. Their structures were elucidated by physicochemical properties and spectral analyses. Results: Ten sesquiterpenes were isolated and identified as 11-methoxyl- guaia-6,10-dien-4α-ol (1), (1R,4S,5R,10R)-isodauc-6-en-10,14-diol (2), 10α-hydroxy-isodauc-6-en-14-al (3), guaia-6,10-dien- 4α,11-diol (4), orientalol B (5), (1S,4R,5R,10S)-isodauc-6-en-10,14-diol (6), (1S,4S,5R,10S)- isodauc-6-en-10,14-diol (7), alismanoid C (8), guaiandiol (9) and canangaterpene VI (10). Conclusion: Compound 1 is a new compound, named as commiphorol A and compounds 2-10 are isolated from the genus for the first time.