Study on mixing technology of post-crosslinking Daphnes Giraldii Cortex gel plaster based on rheological indexes / 中草药

ABSTRACT

Objective: To optimize the mixing technology of Daphnes Giraldii Cortex gel plaster (DGCGP) by using rheological parameters elastic modulus (G'), viscous modulus (G″), yield stress (τ0), creep compliance [J(t)] and loss coefficient (tanδ) as evaluation indexes. Methods: Using orthogonal design, L9(34) orthogonal design was used to screen out the best mixing technology of DGCGP and predict the suitable coating conditions by taking the temperature, rotating speed and mixing time of the mixed materials as influencing factors and the rheological parameters of the medicated compound as evaluating indexes. Results: The optimum DGCGP mixing process was as following 70℃ at 10 r/min for 2 h. Under this condition, the viscoelasticity, temperature and shear resistance, deformation resistance and stability of the mixture were all good. Conclusion: DGCGP prepared by this optimized process had good appearance, soft texture, good adhesion with skin, good viscoelasticity and better quality.