Your browser doesn't support javascript.
loading
Preparation of Lonicerae Japonicae Flos extract supramolecular hydrogel and its release behavior in vitro / 中草药
Chinese Traditional and Herbal Drugs ; (24): 1862-1867, 2020.
Article in Chinese | WPRIM | ID: wpr-846493
ABSTRACT

Objective:

To prepare the Lonicerae Japonicae Flos (LJF) extract supramolecular hydrogel and investigate its properties and release behavior in vitro.

Methods:

The LJF was extracted with 40% ethanol. Taking the content of phenolic acids as the quantitative index, N-(9-fluorenylmethoxycarbonyl)-L-phenylalanine was selected as the gelator to prepare LJF extract supramolecular hydrogels. The release behavior was studied by in vitro release experiment.

Results:

The addition of LJF extract not only did not affect the formation of supramolecular hydrogel, but also improved the stability of supramolecular hydrogel. The release behavior of LJF extract was related to its loading and pH value of release medium. When the drug loading of LJF extract was 0.5 mg/mL, the cumulative release rate was the highest. Moreover, the cumulative release rate increased with the pH value of the release medium, showing obvious controlled release characteristics.

Conclusion:

Supramolecular hydrogels as the release carrier for LJF extract have an obvious sustained and controlled release, which provides a new idea for the development and application of LJF in medicine.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Traditional and Herbal Drugs Year: 2020 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Traditional and Herbal Drugs Year: 2020 Type: Article