Advances on metabolizing enzyme and transporter mediated potential interactions between ciprofloxacin and Chinese materia medica / 中草药

ABSTRACT

The combination of Chinese and Western medicine is common in clinical practice. Ciprofloxacin is one of the most commonly used fluoroquinolones for the treatment of infectious diseases. In order to improve the therapeutic effect of infectious diseases or cope with patients with multiple diseases at the same time, the combination of ciprofloxacin with one or more traditional Chinese medicines is more common. The herb-drug interactions produced by the combination of Chinese materia medica and ciprofloxacin may play an active role in increasing efficacy and reducing toxicity, and may also lead to treatment failure or adverse reactions. The herb-drug interaction mechanisms will occur in the course of absorption (A), distribution (D), metabolism (M), and excretion (E). The effects of drug-metabolizing enzymes and transporters on the ADME process of ciprofloxacin have received much attention in recent years. Therefore, this paper reviews the potential interaction between common Chinese medicine and ciprofloxacin from the perspective of drug-metabolizing enzymes and transporters. It is expected to provide the basis on the rational use of ciprofloxacin and Chinese materia medica.