Immunohistochemical Study of GLI-1 Expression in the Basal Cell Carcinoma of Sun-Exposed and Non-Exposed Areas / 대한피부과학회지
Korean Journal of Dermatology
; : 177-183, 2005.
Article
in Ko
| WPRIM
| ID: wpr-84675
Responsible library:
WPRO
ABSTRACT
BACKGROUND: Basal cell carcinoma (BCC) is the most prevalent cancer in the western world, showing a rapid increase in incidence. Activation of the Sonic hedgehog/Patched (PTCH) and is sisnalling pathway, due to PTCH inactivation, is a key event in sporadic and familial BCC development in humans and is associated with transcriptional activation of specific target genes, including GLI-1. Recently, PTCH inactivation by UV-specific mutation has been reported to develop BCC. OBJECTIVE: To evaluate the expression pattern of GLI-1 oncogene in BCC of sun-exposed and non-exposed areas of skin. METHOD: We examined 20 cases of BCC, and 4 cases of BCC occurring in sun-exposed and non-exposed areas, using an immunohistochemical method with paraffin-embedded sections. RESULTS: The results were as follows. 1. All cases of BCC showed a positive staining for GLI-1 protein. 2. In the staining pattern of GLI-1 protein, BCC in both sun-exposed and non-exposed areas showed diffuse staining throughout the tumor lobules. Moreover, the degree of staining was not found to be different between the BCC of sun-exposed and non-exposed areas. CONCLUSION: These results suggest that increased GLI-1 expression is important for BCC development. And multiple factors, including PTCH mutation due to UV irradiation, may affect GLI-1 expression.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Oncogenes
/
Skin
/
Carcinoma, Basal Cell
/
Transcriptional Activation
/
Incidence
/
Western World
Type of study:
Incidence_studies
/
Prognostic_studies
Limits:
Humans
Language:
Ko
Journal:
Korean Journal of Dermatology
Year:
2005
Type:
Article