Trial of Moxifloxacin-containing Triple Therapy after Initial and Second-line Treatment Failures for Helicobacter pylori Infection / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 111-117, 2005.
Article
in Korean
| WPRIM
| ID: wpr-84686
ABSTRACT
BACKGROUND/AIMS:
Proton-pump inhibitor (PPI)-based triple therapy for Helicobacter pylori eradication is widely used with considerable failure rate. Bismuth-based, second-line therapy is also associated with failures in more than 20% of cases in Korea. Our aim was to evaluate the efficacy and tolerability of third-line therapy containing moxifloxacin as a rescue in Korea.METHODS:
The subjects consisted of 201 patients infected with H. pylori, who were treated with PPI-based therapy, 42 patients treated with bismuth-based after failure of initial PPI triple therapy, and 10 patients treated with moxifloxacin-containing triple therapy after failure of successive initial and second-line therapy. Eradication rate, compliance and side effect rates were compared.RESULTS:
The eradication rates of initial, second-line, and third-line therapy were as follows 67.2%/83.3%, 54.8%/76.7%, 80.0%/88.9% by intention-to-treat and per protocol analysis, respectively. The compliance of patients for each treatment was 98.2%, 90.9%, 100%, respectively. The side effect rate was significantly higher in the bismuth triple therapy than in the PPI- or moxifloxacin-containing triple therapy (p<0.05).CONCLUSIONS:
Moxifloxacin-containing triple therapy shows high eradication rate with fewer side effects and good compliance. Thus, this regimen could be used as a rescue therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quinolines
/
Aza Compounds
/
Bismuth
/
Helicobacter pylori
/
Helicobacter Infections
/
Proton Pumps
/
Drug Therapy, Combination
/
Antacids
/
Anti-Bacterial Agents
Type of study:
Practice guideline
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
The Korean Journal of Gastroenterology
Year:
2005
Type:
Article
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