Exosomes as a disease marker under hypoxic conditions / 中国组织工程研究

ABSTRACT

BACKGROUND: Hypoxia is a common physiological and pathological stress response in various diseases, and exosomes are widely involved in the mechanism of hypoxia injury and its adaptive mechanism. The two are closely related, which is the current research hotspot. OBJECTIVE: To find a new target for the prevention and treatment of high altitude diseases and open up new ideas. METHODS: The PubMed and Medline databases from 2013 to 2020, and the CNKI and Wanfang databases from 2018 to 2019 were searched by computer. The key words were “serum exosomes, hypoxia, tumor, inflammation, cardiovascular and cerebrovascular diseases” in Chinese and English. Finally, 57 articles were included in the review. RESULTS AND CONCLUSION: Hypoxia is a potential environmental death factor by affecting cell cycle, morphology, metabolism, proliferation, differentiation, autophagy, apoptosis and so on. Hypoxia can regulate the release and change the content of exosomes, which is strongly associated with cell specificity, the duration of hypoxia exposure and the severity of hypoxia. In the environment of hypoxia, exosomes can transmit all kinds of biological information and play an important role in biology through specific binding with receptor cells. As a biomarker of disease diagnosis, exosomes have great potential.