Related factors regulating osteogenic differentiation of bone marrow mesenchymal stem cells through Wnt/β-catenin signaling pathway / 中国组织工程研究

ABSTRACT

BACKGROUND: Bone marrow mesenchymal stem cells induce osteogenesis and inhibit adipocyte differentiation, which is the key to the prevention and treatment of osteoporosis and the source of seed cells for bone tissue repair engineering. Wnt signaling pathway plays an important role in bone formation. OBJECTIVE: To review the related factors and molecular mechanisms that regulate osteogenic differentiation of bone marrow mesenchymal stem cells through Wnt/β-catenin signaling pathway. METHODS: CNKI, PubMed and Wanfang Medical Database were retrieved by computer for related literatures published from inception to February 2020. The Chinese key words were “bone marrow mesenchymal stem cells, osteoporosis, osteogenic differentiation, osteocytes, extracellular matrix, osteoarthritis, Wnt, β-catenin”. The English key words were “BMSCs, osteoarthritis, Wnt/β-catenin, Wnt”. Finally, 62 articles were included in the review. RESULTS AND CONCLUSION: The relevant factors can directly or indirectly regulate the osteogenic differentiation of bone marrow mesenchymal stem cells through the Wnt/β-catenin signaling pathway. There are positive promotion, negative inhibition and even loop regulation due to the interaction between various factors. The Wnt/β-catenin signaling pathway is a key signal for osteogenic differentiation of bone marrow mesenchymal stem cells. The systematic analysis of the molecular mechanism of osteogenic differentiation of bone marrow mesenchymal stem cells provides a theoretical basis for bone tissue engineering, and can realize the application of bone tissue engineering faster.