Role and hotspots of stem cell-derived exosome in the repair of traumatic brain injury / 中国组织工程研究

ABSTRACT

BACKGROUND: The treatment and prognosis of traumatic brain injury are difficult points in clinical work at present. More and more studies have shown that exosomes derived from stem cells show unique advantages in traumatic brain injury, which may have greater neurotherapeutic potential in the treatment of traumatic brain injury, and may essentially restore neurovascular function and promote neuronal regeneration, thereby providing new ideas for the treatment of traumatic brain injury. OBJECTIVE: To review the application and advantages of exosomes derived from stem cells in traumatic brain injury. METHODS: A computer-based search was performed in the PubMed and CNKI databases for articles addressing exosomes. The keywords were “Traumatic brain injury, Exosomes, Stem cells” in English and Chinese, respectively. Finally, 53 articles were included for review. RESULTS AND CONCLUSION: (1) A large number of traumatic brain injury animal experiments proved that nerve cells and stem cells can secrete exosomes. (2) Exosomes derived from nerve cells and stem cells play a positive role in the treatment of traumatic brain injury, but the exosomes derived from stem cells are more effective in nerve, vascular regeneration and neurofunctional recovery. (3) The exosomes derived from stem cells may open up a new approach to traumatic brain injury.