An analysis of pathogenic bacteria infection in 422 kidney transplant recipients / 中国组织工程研究

ABSTRACT

BACKGROUND: In this study, we investigated the types and characteristics of bacterial infections in kidney transplant recipients, and analyzed the distribution of pathogenic bacteria for nosocomial infections and the changes in bacterial resistance after kidney transplantation, with the attempt to provide accurate and effective measures for prevention and treatment of bacterial infection and achieve the rational clinical use of antimicrobial drugs for kidney transplant recipients. OBJECTIVE: To investigate the epidemiological characteristics of nosocomial infection in renal transplant recipients. METHODS: A total of 422 patients with pathogenic bacteria infection after kidney transplantation in the Center of Kidney Transplantation, Zhengzhou People’s Hospital were investigated from August 2014 to August 2019, including specimen types, distribution of pathogenic bacteria and drug resistance of pathogens. The implementation of this study complied with the relevant ethical requirements of Zhengzhou People’s Hospital. RESULTS AND CONCLUSION: Positive specimens of pathogenic bacteria infection after kidney transplantation were from sputum, urine and peripheral blood mainly. Of the 422 strains of pathogenic bacteria, 274 strains (64.9%) were gram-negative, 75 strains (17.8%) were gram-positive and 73 strains (17.3%) were fungi. Among them, gram-negative bacteria were isolated from Klebsiella pneumoniae, Acinetobacter and Escherichia coli. Staphylococcus aureus, Enterococcus faecium and Staphylococcus epidermidis had higher isolation rate of gram-positive bacteria. The resistance rate of gram-negative bacteria to most antimicrobial agents was high. The gram-positive bacteria tested had different degrees of resistance to the other antimicrobial agents besides being completely sensitive to vancomycin, teicoplanin and linezolid. To conclude, gram-negative bacteria are the main pathogenic bacteria in kidney transplantation recipients. Most of the pathogenic bacteria are highly resistant to many antibiotics, and some of them have developed multiple resistance. We should strengthen the supervision of drug resistance of recipients after kidney transplantation and rationally use antibiotics.