The use of epigallocatechin gallate prevents white spot lesions during orthodontic treatment with fixed appliances / 中国组织工程研究

ABSTRACT

BACKGROUND: Plenty of studies have already proved the effective usage of epigallocatechin gallate (EGCG) in clinical treatment. However, no current research has focused on the application of EGCG in preventing white spot lesions (WSLs) during orthodontics treatment with fixed appliances. OBJECTIVE: To study the value of EGCG in the prevention of WSLs during orthodontic treatment with fixed appliances. METHODS: In total 50 patients undergoing orthodontic treatment with fixed appliances were carefully screened and enrolled. Split-mouth design was adopted the right side of teeth received experimental adhesive (1 g/L EGCG + Adper™ Single Bond 2); the left side of teeth acted as control. All the other clinical procedures and materials used were same. The enamel demineralization index (EDI) and the WSLs prevalence of targeted teeth (16, 11, 46, 26, 31, and 36) were detected at 3, 6, and 12 months during the treatment, and the percentage of bracket bonding failure was calculated for each group. The study protocol was implemented in line with the relevant ethical requirements of Liuzhou People’s Hospital. Patients and their guardians were fully informed of the whole trial procedures. RESULTS AND CONCLUSION: In this trial, the percentage of bracket bonding failure was significantly different between the EGCG group and control group (P > 0.05). After 3 months of treatment, the values of WSLs and EDI had no significant difference between the EGCG group and control group (P > 0.05). However, after 6 months and 12 months treatment, the EGCG group manifested significantly lower WSL and EDI values than the control group (P < 0.05). Therefore, addition of the adhesive containing 1 g/L EGCG has a considerable effect in preventing enamel demineralization and the occurrence of WSLs without influencing the enamel bonding strength, and it has a long-time effect which deserves the clinical expansion.