Effect of Tamsulosin, a Selective alpha1A-adrenoreceptor Antagonist, in Benign Prostatic Hyperplasia / 대한비뇨기과학회지
Korean Journal of Urology
;
: 158-166, 1997.
Article
in Korean
| WPRIM
| ID: wpr-84737
ABSTRACT
OBJECTIVE:
To evaluate the efficacy and safety of tamsulosin, a selective alpha1Aadrenoreceptor antagonist in the treatment of urinary outflow obstruction associated with benign prostatic hyperplasia (BPH) in Korean patients. PATIENTS ANDMETHODS:
The study was a single-blind and randomized design. Tamsulosin, fixed dose of 0.2 mg was taken once daily for 8 weeks. In control group, terazosin, a non-selective c 1-adrcnoreceptor antagonist was administrated with escalating dose of 1 to 5 mg once daily. The study enrolled 98 patients, and 72 patients were included in the analyses at weeks 4 and 8.RESULTS:
Both tamsulosin and terazosin had similar significant improvements in subjective and objective symptoms of urinary outflow obstruction (p<0.05). Systolic and diastolic blood pressures decreased significantly in the terazosin-treated patients (p<0.05). Adverse events, most frequently dry mouth and dizziness, usually mild and transient, were observed significantly more in patients on terazosin (18 patients versus I patients on tamsulosin, p<0.001) and led to discontinuation of therapy in two patients on terazosin.CONCLUSION:
Tamsulosin, a selective 1A-adrcnorcccptor antagonist, was effective in urinary outflow obstruction associated with BPH. The efficacy of tamsulosin was similar to terazosin, but had a marked better safety profile.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostatic Hyperplasia
/
Dizziness
/
Mouth
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Urology
Year:
1997
Type:
Article
Similar
MEDLINE
...
LILACS
LIS