T2-mapping quantitative imaging technique based on sequence optimization in the ankle talus osteochondral injury / 中国组织工程研究

ABSTRACT

BACKGROUND: At present, DWI, DTI, T1-mapping, T2-mapping, and T2*-mapping are commonly used in cartilage functional imaging sequences in both scientific research and clinic. T2-mapping is often used for the quantitative analysis of cartilage, but it was obviously limited due to the long scanning time and poor experience of the patient.OBJECTIVE: To quantitatively evaluate the talar cartilage injury degree of chronic lateral ankle instability patients by sequence optimized T2-mapping quantitative imaging technique. METHODS: Totally 53 cases of chronic ankle instability(case group) and 46 healthy subjects(control group) were from the Second Affiliated Hospital of Inner Mongolia Medical University. They underwent conventional Magnetic Resonance Imaging and optimal T2-mapping quantitative imaging scanning. The total talar cartilage was divided into six compartments internal anterior, internal medial, internal posterior, lateral anterior, lateral center and lateral posterior. Six T2 values were totally taken as each partition had one T2 value. The experiment was approved by the Ethics Committee of Inner Mongolia Medical University. RESULTS AND CONCLUSION: The T2 values of internal anterior, internal medial, internal posterior areas of case group were higher than those of control group(P 0.05). The results showed that the talus cartilage injury mainly occurred in the internal talus in patients with chronic lateral ankle instability. The cartilage damage degree could be quantitatively evaluated by magnetic resonance T2-mapping imaging technique. It is possible that T2-mapping based on sequence optimization can be used in functional image routine scan.