Mechanism by which autophagy-mediated exercise improves bone metabolic disorder in type 2 diabetes / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
;
(53): 3256-3262, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-847482
ABSTRACT
BACKGROUND:
Autophagy can regulate bone metabolism disorders in type 2 diabetes mellitus via nuclear factor KB receptor activating factor ligand, mammalian target of rapamycin, Wnt/β-catenin pathway, and p38 mitogen-activated protein kinase.OBJECTIVE:
To analyze and summarize the role and possible molecular mechanism of autophagy to improve bone metabolism disorder in type 2 diabetes mellitus.METHODS:
Using “autophagy; exercise; type 2 diabetes mellitus; bone metabolism” as keywords, we retrieved literature regarding autophagy for improving bone metabolism disorder in type 2 diabetes mellitus in PubMed and China Knowledge Network, and logically analyzed and summarized the included studies. RESULTS ANDCONCLUSION:
Autophagy can improve bone metabolism disorders in type 2 diabetes mellitus through activation of signaling pathways, such as PPAR-γ, Hedgehog, MITF, and peroxisome proliferator-activated receptors. Autophagy can up-regulate the differentiation capacity of osteoblasts, down-regulate the absorption capacity of osteoclasts in type 2 diabetes mellitus, and has an important effect on bone formation and osteocalcin mineralization.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Tissue Engineering Research
Year:
2020
Type:
Article
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