Biological oxygen-carrying therapeutic agents: Roles and applications / 中国组织工程研究

ABSTRACT

BACKGROUND: Although blood donation by healthy people can relieve the urgent need of clinical blood to some extent, it is impossible to fundamentally solve the problem of blood shortage and blood safety by relying solely on blood donation by healthy people. OBJECTIVE: In combination with the significance of the development of biological oxygen-carrying therapeutics, to expound the unique characteristics of biological oxygen-carrying therapeutics, and to summarize the research status and application progress of biological oxygen-carrying therapeutics in recent years, in order to provide a certain theoretical basis for further research on the role and clinical application of biological oxygen carrying therapeutic agents. METHODS: The authors searched the relevant articles published from January 2015 to August 2019 in the databases of CNKI, Wanfang and PubMed. The keywords were “blood substitute, hemoglobin oxygen carrier, artificial blood, oxygen-carrying therapeutic agent” in English and Chinese. Types of search literature included original research and reviews. Initially 418 articles were included, and finally 46 eligible articles were classified and reviewed. RESULTS AND CONCLUSION: The biological oxygen-carrying therapeutic agent has a good clinical effect. It can maintain blood osmotic pressure, acid-base balance and blood volume, and also has good oxygen-carrying capacity. It can deliver oxygen to local hypoxic tissue for a long time. It is also easy to store and transport. Biological oxygen-carrying therapeutic agents have been widely used in surgery, which are of great help to expand blood volume and accelerate postoperative recovery. Therefore, the development of biological oxygen-carrying therapeutic agents is of great significance for surgical trauma and resuscitation, hemorrhagic shock, malignant anemia, myocardial infarction and other diseases. It shows a good clinical application prospect.