Tau protein and alzheimer’s disease / 中国组织工程研究

ABSTRACT

BACKGROUND: Deposition of neurofibrillary tangles is closely related to cognitive decline in Alzheimer’s disease, and tau protein is an important component. OBJECTIVE: To investigate the possible pathogenesis of Alzheimer’s disease and the role of tau protein hyperphosphorylation in the progression of Alzheimer’s disease. METHODS: The first author searched for relevant articles published from January 2001 to January 2019 in WanFang, CNKI, Vip, PubMed, and Embase with the key words of “Alzheimer’s disease; tau protein; β-amyloid cascade.” RESULTS AND CONCLUSION: Hyperphosphorylation of tau protein and formation of paired helix filaments are considered to be the basis of neuronal degradation in Alzheimer’s disease. tau protein may not depend on the cascade response triggered by β-amyloid deposition in the pathogenesis of Alzheimer’s disease, and tau protein-associated vaccine immunity has been verified to produce a curative effect in clinical trials. Further exploration on the relationship between tau protein, β-amyloid protein and Alzheimer’s disease is necessary to better understand the pathogenesis of Alzheimer’s disease, and provide a theoretical basis for the development of therapeutic drugs for Alzheimer’s disease.