Role of angiogenesis in dental pulp regeneration: Exosomes and angiogenic factors / 中国组织工程研究

ABSTRACT

BACKGROUND: With the application of tissue engineering technology In the field of stomatology, It Is possible to construct a tissue-engineered dental pulp for the regeneration of dentin-pulp complex. Formation of new blood supply system through angiogenesis Is mandatory to dental pulp regeneration. Angiogenesis is defined as the formation of new blood vessels from preexisting capillaries, which has great significance in pulp regeneration and homeostasis. OBJECTIVE: To review the contribution of exosomes and angiogenic factors to angiogenesis in the dental pulp. METHODS: A search of PubMed and CNKI was performed for relevant literature published from 2017 through 2019. The search terms were "tissue engineering, pulp regeneration, regenerative endodontics, angiogenesis, neovascularization, angiogenic, signal molecules, exosomes, factors, role, mechanism" In English and Chinese, respectively. RESULTS AND CONCLUSION: Many studies have indicated an intimate relationship between angiogenesis and dental pulp regeneration. The contribution of exosomes and angiogenic factors to angiogenesis of the dental pulp has been previously discussed. Angiogenesis is an indispensable process during dental pulp regeneration. The survival of transplanted pulp tissue is closely linked to the process of angiogenesis at sites of application. However, further Investigations are warranted on the detailed regulatory mechanisms of exosomes and factors Involved In Initiation and progression of angiogenesis In pulp tissue.