Meta-analysis of efficacy and safety of light therapy combined with sodium hyaluronate in the treatment of knee osteoarthritis / 中国组织工程研究

ABSTRACT

Background: A large number of studies have confirmed that light therapy combined with sodium hyaluronate has a significant effect on knee osteoarthritis. The combination use is highly safe, but there is still lack of evidence-based evidence. OBJECTIVE: To perform a meta-analysis of light therapy combined with sodium hyaluronate for knee osteoarthritis. METHODS: English databases (PubMed, OVID, EMBASE) and Chinese databases (CNKI, WanFang, VIP, China Biomedical Literature Database) were retrieved by computer for relevant articles regarding randomized controlled trials of light therapy combined with sodium hyaluronate In the treatment of knee osteoarthritis. The search time was from the Inception to July 1, 2019. The quality of the Included studies was evaluated and relevant clinical data In the literature were extracted. The results were analyzed by RevMan 5.3. RESULTS AND CONCLUSION: A total of 16 articles were Included, Involving 1 505 patients. The experimental group was treated with light therapy combined with sodium hyaluronate, and the control group was treated with sodium hyaluronate. The meta-analysis results showed that compared with the control group, the experimental group showed higher total clinical effective rate (odds ratio (OR)=4.20, 95% confidence interval (CI) [2.75, 6.39], P < 0.000 01), higher cure rate (OR=2.62, 95%C/[1.78, 3.86], P < 0.000 01), lower visual analogue scale score (mean difference (MD)=-1.51, 95%C/[-2.15, -0.87], P < 0.000 01), and better Lysholm score (MD=13.30, 95%C/[6.82,19.78], P < 0.000 01). There was no significant difference in the incidence of adverse reactions between the experimental and control groups (OR=0.64, 95%С/ [0.25,1.63], P=0.35). Light therapy combined with sodium hyaluronate for knee osteoarthritis has greater advantages than intraarticular injection of sodium hyaluronate alone, with high efficacy and safety. However, further Investigations with high-quality and large sample size randomized controlled studies are still warranted.