Effect and mechanism of traditional Chinese medicine for replenishing qi and promoting blood combined with bone marrow mesenchymal stem cells in promoting angiogenesis in ischemic stroke / 中国组织工程研究

ABSTRACT

BACKGROUND: Bone marrow mesenchymal stem cells have the effect of promoting angiogenesis, and have shown a good therapeutic effect in the study of ischemic stroke. Traditional Chinese medicine for replenishing qi and activating blood also has a significant effect in promoting angiogenesis. OBJECTIVE: To summarize the mechanism of traditional Chinese medicine for replenishing qi and activating blood combined with bone marrow mesenchymal stem cells in promoting angiogenesis in ischemic stroke, so as to provide reference for the research and treatment of ischemic stroke. METHODS: “Bone marrow mesenchymal stem cells, angiogenesis, ischemic stroke, traditional Chinese medicine” were used as the English and Chinese key words. We searched the literatures regarding the related mechanism of angiogenesis and the literature related to angiogenesis promoted by traditional Chinese medicine combined with bone marrow mesenchymal stem cells in PubMed, CNKI and Wanfang databases from 2009 to 2020. The literatures with weak correlation and repetition were excluded, and 145 literatures were summarized and analyzed. RESULTS AND CONCLUSION: (1) The definition of bone marrow mesenchymal stem cells and angiogenesis and the mechanism of promoting angiogenesis were combed. (2) The related factors and signal pathways of replenishing qi and activating blood traditional Chinese medicine combined with bone marrow mesenchymal stem cells to promote angiogenesis were summarized, such as vascular endothelial growth factor, brain-derived neurotrophic factor, basic fibroblast growth factor, hypoxia-inducible factor-1α, angiopoietin, integrin αvβ3, matrix metalloproteinase-9 and Wnt signal pathway, Notch signal pathway, PI3K/Akt signal pathway and SDF-1/CXCR4 signal axis. (3) It is found that the combination of traditional Chinese medicine for replenishing qi and activating blood and bone marrow mesenchymal stem cells can promote angiogenesis and improve the therapeutic effect on ischemic stroke.