Clinical application and focus of lars ligament in anterior cruciate ligament reconstruction / 中国组织工程研究

ABSTRACT

BACKGROUND: Although there are three main types of graft selection for anterior cruciate ligament reconstruction: Autograft, allogeneic graft and synthetic graft, graft selection is still the focus of current research and controversy. OBJECTIVE: To review the early, mid-term and long-term clinical effects of LARS ligament in the reconstruction of arthroscopic anterior cruciate ligament. METHODS: The related literatures published before April 2019 in CNKI database and PubMed database were searched by computer with the search terms “LARS ligament, anterior cruciate ligament, artificial ligament, anterior cruciate ligament reconstruction” in Chinese and English respectively. After preliminary screening by reading titles and abstracts, irreverent literatures were excluded. Forty-six eligible literatures were included. RESULTS AND CONCLUSION: LARS ligament had excellent biocompatibility and mechanical properties. Its unique structure allowed fibroblasts to grow in the forms of wrapping and penetration, and there was no inflammatory reaction around the ligament and fewer macrophages were observed. Because the growing tissue increased the viscoelasticity of the ligament and reduced the friction between the fibers, so it can effectively prevent the biological reaction caused by detritus. LARS ligament had good elastic modulus, anti-torsion and fatigue resistance properties. LARS ligament was suitable for anterior cruciate ligament reconstruction because of its rapid recovery, low failure rate, and few complications.