Effects of 1,25(Oh)2d3 on microrna-130b and transforming growth factor beta 1 in renal tissue of rat models of diabetic nephropathy / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
;
(53): 248-253, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-848092
ABSTRACT
BACKGROUND:
1,25(OH)2D3 plays an important regulatory role in the development of diabetic nephropathy.OBJECTIVE:
To explore the effect of 1,25(OH)2D3 on the expression of microRNA-130b and transforming growth factor pi in kidney of diabetic nephropathy rats.METHODS:
The study was approved by the Laboratory Animal Ethical Committee of Laboratory Animal Center of Xinjiang Medical University. Twenty-five clean Sprague-Dawley rats were randomly divided into normal control group, diabetic nephropathy+1,25(OH)2D3 group and diabetic nephropathy+peanut oil group. The latter two groups were given calcitriol (1,25(OH)2D3, active vitamin D3, 0.03 jg/kg
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Tissue Engineering Research
Year:
2020
Type:
Article
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