Human amniotic membrane, drugs, and growth factors prevent adhesion after repair of tendon injury / 中国组织工程研究

ABSTRACT

BACKGROUND: Strong evidence exists that tendon adhesion occurs after tendon repair. OBJECTIVE: To review the advance in research on the prevention of tendon adhesion in terms of human amniotic membrane, drugs and growth factor. METHODS: A computer-based online search of Wanfang, CNKI, and Medline databases was performed to search papers regarding prevention of adhesion after tendon injury published between January 2000 and April 2019 with the search terms “tendon injury, tendon adhesions, drug, human amniotic membrane, growth factor” in English and Chinese. Papers recently published in high-impact journals in the same research field were selected. Fifty papers were included in the final analysis. RESULTS AND CONCLUSION: Amniotic membrane and acellular amniotic membrane are effective in preventing tendon adhesion. Drugs can work in many ways to achieve the purpose of preventing adhesion, and drugs exhibit better efficacy after combined application with sustained-release carrier. Most growth factors not only promote tendon healing but also promote adhesion formation. The formation of tendon adhesion can be reduced by adjusting the concentration of growth factors in the lesion site.