Biological reconstruction of large bone defects after resection of malignant tumor of extremities / 中国组织工程研究

ABSTRACT

BACKGROUND: With the development of medical technology, limb salvage surgery for malignant bone tumors has gradually become the main trend, so various biological reconstruction methods can be cited in the clinic. OBJECTIVE: To review the biological reconstruction of large bone defects after resection of malignant tumor of extremities. METHODS: The literature about the biological reconstruction of large bone defects after resection of malignant tumor of extremities was reviewed in PubMed, Web of Science, Wanfang, and CNKI from 2000 to 2020 by the first author using computer. The English key words were “malignant bone tumor, bone defect, biological reconstruction, limb salvage”, and the Chinese key words were “malignant bone tumor, limb salvage, biological reconstruction”. The documents that did not match the central words were eliminated, and the advantages and disadvantages of various biological reconstruction surgery methods were summarized. RESULTS AND CONCLUSION: (1) Analyzing the in-situ devitalized tumor-bearing bone, biological reconstruction after resection of juxta-articular osteosarcoma segmental bone tumor, each has its advantages and disadvantages. Surgeons should choose different operation methods based on its different indications. (2) Biological reconstruction provides vital methods for limb salvage of malignant tumor of extremities.