Bone marrow mesenchymal stem cells and tongue squamous carcinoma cells: Promoting growth or targeting biotherapy / 中国组织工程研究

ABSTRACT

BACKGROUND: Currently, the treatment methods for tongue squamous cell carcinoma mainly adopt comprehensive sequence therapy mainly based on surgery, but the therapeutic effect is still unsatisfactory. In recent years, tumor targeted biotherapy has attracted increasing attention. Stem cell technology enables therapeutic factors to be selectively delivered to tumor sites to play corresponding roles. Bone marrow mesenchymal stem cells show great advantages in this respect. However, the effect and action mechanism of bone marrow mesenchymal stem cells on tongue squamous cell carcinoma are still unclear. OBJECTIVE: To review the research progress on the effect of bone marrow mesenchymal stem cells on tongue squamous carcinoma cells, and clarify its function and discuss its mechanism. METHODS: The computer was used to search literatures about bone marrow mesenchymal stem cells in PubMed database, Wanfang database and CNKI database. The key words were “bone marrow mesenchymal stem cells, tumor cells”, “bone marrow mesenchymal stem cells, tongue squamous cell carcinoma”, “bone marrow mesenchymal stem cells, proliferation”, “bone marrow mesenchymal stem cells, migration, invasion” in Chinese, and “bone marrow mesenchymal stem cells, cancer cells” and “bone marrow mesenchymal stem cells, tongue squamous cell carcinoma”, “bone marrow mesenchymal stem cells, proliferation”, “bone marrow mesenchymal stem cells, migration, invasion” in English. A total of 43 articles were included for analysis. RESULTS AND CONCLUSION: Bone marrow mesenchymal stem cells have strong proliferation characteristics and can migrate directionally and promote invasion of tongue squamous carcinoma cells, suggesting that even if bone marrow mesenchymal stem cells have the function of promoting defect repair, and can also express therapeutic factors by gene modification and migrate to tumor growth site to play a therapeutic role, they cannot be used for repair treatment of postoperative defects of tongue squamous cell carcinoma. Targeted biological therapy of mesenchymal stem cells is a brand-new and promising field, but its safety still needs to be taken into account, and its mechanism of action and potential risks still need our continuous exploration.