Secular trends of incidence and mortality of ovarian cancer in changning district of shanghai, 1973-2013 / 肿瘤

ABSTRACT

Objective: To analyze the secular trends of incidence and mortality of ovarian cancer in the Changning district of Shanghai, 1973-2013. Methods: Using the data from Shanghai Cancer Registry, the crude rates of incidence and mortality, and the age-standardized rates (ASRs) by Chinese standard population and Segi’s world standard population were calculated for ovarian cancer in the Changning district of Shanghai, 1973-2013. Joinpoint software was utilized to analyze the secular trends of incidence and mortality, as well as to calculate the annual percent changes (APCs) and average annual percent changes (AAPCs). Age-period-cohort model was performed to further investigate the contributions of age, period and cohort effects on the secular trends of incidence and mortality. Results: Total of 936 new incidence cases and 504 deaths in the Changning district of Shanghai were identified during 1973-2013. The crude incidence rate, age-standardized incidence rates by Chinese standard population and Segi’s world standard population were 8.72/105, 6.32/105 and 6.00/105, respectively. The crude mortality rate, age-standardized mortality rates by Chinese standard population and Segi’s world standard population were 4.70/105, 2.99/105 and 2.92/105, respectively. The crude incidence rate, age-standardized incidence rates by Chinese standard population and Segi’s world standard population of ovarian cancer showed steady rising trends during 1973-2013, by an average of 2.96%, 1.51% and 1.63% per year, respectively. The crude mortality rate increased by an average of 2.53% per year, but the secular trends of age-standardized mortality rates by Chinese standard population and Segi’s world standard population were not significant (both P > 0.05). Age-period-cohort analysis showed that both the incidence and mortality rates of ovarian cancer increased with age (both P 0.05). Conclusion: The crude incidence rate, age-standardized incidence rates by Chinese standard population and Segi’s world standard population, and crude mortality rate of ovarian cancer in the Changning district of Shanghai show steady rising trends during 1973-2013. The secular trends of age-standardized mortality rates by Chinese standard population and Segi’s world standard population are not significant. Both the incidence and mortality rates increased with age, suggesting the elderly women are key population for the prevention of ovarian cancer. ovarian cancer.