Signal transduction mechanism and targeted therapy of melanoma stem cells / 肿瘤

ABSTRACT

Melanoma is the most serious type of skin cancer with high metastasis potential and very low survival rate. Although the molecular targeted therapy and immunotherapy have prolonged the survival time of some patients with melanoma in the past few years, a considerable number of patients still can not obtain a longer stable remission period. According to the recent study, melanoma stem cells (MSCs) are one of potential causes of tumor invasion, drug resistance, distant metastasis and recurrence. MSCs can express a variety of cellular markers, and participate into the regulation of tumor-related signal transduction. At the same time, these signaling pathways can retroregulate the expression of cellular markers, and promote the development of melanoma. Therefore, targeting MSCs markers and blocking the related signal transduction pathway can inhibit the growth of melanoma. In this review, the cellular markers, signal transduction mechanism and targeted therapy of MSCs have been discussed in order to provide new ideas for the treatment of melanoma.