Correlation between abnormity of T cell subsets and outcome of autologous hematopoietic stem cell transplantation in patients with lymphoma / 肿瘤

ABSTRACT

Objective: To analyze the effect of abnormal T cell subsets on the prognosis of patients with lymphoma after autologous hematopoietic stem cell transplantation (AHSCT). Methods: The clinical data of 55 patients with lymphoma who receivedAHSCT from January 2016 to December 2017 were collected. The correlation of abnormal T cell subsets with the outcome of AHSCT was analyzed retrospectively, and the effect of abnormal T cell subsets on the prognosis of patients after AHSCT was evaluated. Results: The age of lymphoma patients was correlated with the increased percentages of CD3+ cells and CD3+CD16+CD56+ cells and the decreased percentage of CD19+ cells (all P 0.05). Relapsed/refractory lymphomas and the decreased percentage of CD3-CD16+CD56+ cells were identified as independent risk factors for the progression/relapse of tumor after AHSCT (both P < 0.05). Based on the stratification by these two factors, the incidence of progression/relapse after AHSCT was 10.0%, 32.3% or 100.0% in the patients without risk factor, with 1 or 2 risk factors, respectively (P = 0.001). Conclusion: The abnormal T cell subsets may be a poor prognostic factor for the patients with lymphoma received AHSCT.