Prognostic value of combination of preoperative platelet and red blood cell distribution width in patients with non-small cell lung cancer / 肿瘤

ABSTRACT

Objective: To investigate the correlation of the combination of preoperative platelet and red blood cell distribution width (COP-RDW) with the prognosis of patients with non-small cell lung cancer (NSCLC). Methods: The clinical data of 495 patients with NSCLC who underwent radical resection surgery in Tianjin Medical University Cancer Institute and Hospital from 2004 to 2008 were collected. The optimal cut-off values of preoperative platelet (PLT) and red blood cell volume distribution width (RDW) were calculated using the receiver operating characteristic (ROC) curve. Based on the cut-off point, all of the cases were further categorized into three groups according to the COP-RDW scores of 0, 1 and 2. The relationship between the clinicopathological factors and COP-RDW scores were analyzed by χ2 test or Fisher’s exact test. The survival rate curves were drawn using Kaplan-Meier method, and the differences of the survival curves were compared by log-rank test. Univariate and multivariate COX regression analyses were performed to analyze the prognostic variables. R esults ROC analysis showed that the optimal cut-off points of PLT and RDW were 253×109/L and 12.95%, respectively. Kaplan-Meier analysis displayed significant differences among the different COP-RDW score groups. The 5-year overall survival (OS) rates of patients with COP-RDW scores of 0, 1, and 3 were 60.7%, 48.7% and 34.3%, respectively (P < 0.001). The 5-year disease-free survival (DFS) rates in the three groups were 62.5%, 45.8% and 28.9%, respectively (P < 0.001). In the subgroup analyses of the pathological stages, COP-RDW score was correlated with 5-year OS rates and 5-year DFS rates of patients at stage I-III. Multivariate analysis demonstrated that the pathological stage and COP-RDW score were independent risk factors for the prognosis of NSCLC patients (both P < 0.001). Conclusion: COP-RDW score represents a negative independent prognostic indicator in NSCLC patients, may become a useful marker to predict the prognosis of patients with early-stage NSCLC.