Expression of lncrna KCNQ1OT1 in DLBCL patients and its clinical significance / 肿瘤

ABSTRACT

Objective: To investigate the expression of long non-coding RNA (LncRNA) KCNQ1 overlapping transcript 1 (KCNQ1OT1) in the peripheral blood of patients with diffuse large B-cell lymphoma (DLBCL), and to analyze its clinical significance. Methods: The expression of LncRNA KCNQ1OT1 in the serum samples of 120 DLBCL patients and 55 non-tumor patients (as the control group) was detected by real-time fluorescent quantitative PCR. The correlations of LncRNA KCNQ1OT1 expression with the clinicopathological features and prognosis of DLBCL patients were analyzed. Results: The expression level of LncRNA KCNQ1OT1 in the serum of DLBCL patients was higher than that in the control group (P < 0.001). The expression of LncRNA KCNQ1OT1 was correlated with the tumor size, Ann Arbor stage, B symptoms, chemosensitivity and the international prognostic index (IPI) (all P < 0.001). The progression-free survival (PFS) time and the overall survival (OS) time of DLBCL patients with LncRNA KCNQ1OT1 high expression were significantly shorter than those with LncRNA KCNQ1OT1 low expression (both P < 0.001). Ann Arbor stage, LncRNA KCNQ1OT1 expression, IPI and chemosensitivity were the independent prognosis factors for DLBCL patients (all P < 0.01). Conclusion: LncRNA KCNQ1OT1 is highly expressed in the serum of patients with DLBCL, and is one of independent prognosis factors for DLBCL patients.