Advances in the role of exosomes in gastric cancer / 肿瘤

ABSTRACT

Exosomes is a kind of nano-sized vesicles secreted into the extracellular environment. Exosomes contain many bioactive molecules including proteins, nucleic acids and lipids. Exosomes participate in the exchange of substances and information between cells, thus playing important roles in many physiological and pathological processes. In recent years, exosomes are found to be critically involved in the occurrence, development, metastasis and drug resistance of gastric cancer. Exosomes are present in various types of body fluids including blood and gastric juice. The detection of proteins and nucleic acids in exosomes from grastic cancer patients will be helpful to the early diagnosis, the evaluation of therapeutic effects, and the prediction of prognosis. This review summarizes the role, mechanism and clinical significance of exosomes in gastric cancer, in order to provide some new ideas and methods for the early diagnosis and treatment of gastric cancer.