Expressions of runt-related transcription factor 2 and osteopontin in breast cancer tissues and their clinical significance / 肿瘤

ABSTRACT

Objective: To investigate the expressions of Runt-related transcription factor 2 (RUNX2) and osteopontin (OPN) proteins in breast cancer tissues, and to explore their clinical significance. Methods: The expression levels of RUNX2 and OPN proteins in tumor tissues of 220 patients with breast cancer were detected by immunohistochemical staining method. The relationships between the expression levels of RUNX2 and OPN proteins and the clinicopathological features, such as tumor microcalcification, TNM staging and pathological types of breast cancer were analyzed. The overall survival (OS) time and disease-free survival (DFS) time of patients with breast cancer were followed up. The effects of RUNX2 and OPN expression levels on the prognosis of breast cancer patients were also analyzed. Results: The positive rates of RUNX2 and OPN proteins in calcification group were higher than those in non-calcification group (90.9% vs 82.7%, 96.4% vs 83.6%, both P 0.05). Conclusion: RUNX2 and OPN are highly expressed in microcalcification of breast cancer, which suggests that they may participate in the process of microcalcification formation in breast cancer tissues. RUNX2 is an adverse prognostic factor for DFS and OS of breast cancer patients. However, OPN has no effect on the survival of breast cancer patients.