Prognostic value of ALBI grading in patients with hepatocellular carcinoma treated with repeated TACE / 肿瘤

ABSTRACT

Objective: To evaluate the prognostic value of albumin-bilirubin (ALBI) grading and Child-Pugh grading in hepatocellular carcinoma patients undergoing repeated transarterial chemoembolization (TACE). Methods: A retrospective analysis was made for 233 hepatocellular carcinoma patients who received repeated TACE treatment from September 2014 to June 2016 in Department of Gastroenterology of Chinese People’s Armed Police Force Characteristic Medical Center and Department of Gastroenterology of Tianjin First Central Hospital. The prognostic value of ALBI grading and Child-Pugh grading was analyzed and compared by Kaplan-Meier method, and log-rank test was used to detect the difference between the two groups. Furthermore the difference of ALBI grading and Child-Pugh grading in the quality of life was evaluated using Medical Outcome Study 36-item short-from health survey (SF-36) scale after 2 weeks of treatment. Results: The levels of aspartate transaminase (AST), alanine aminotransferase (ALT), platelet count, total bilirubin, albumin and prothrombin time activity in ALBI-1 group were better than those in ALBI-2 group. Only three months after the first TACE treatment, 13.96% of the patients had progress in Child-Pugh grading (χ2 = 33.471, P 0.05). Conclusion: ALBI score has a certain value in predicting liver function and outcome after repeated TACE treatment, which is worthy of further study.