Research progress of histone lysine demethylase KDM5A in tumors / 肿瘤

ABSTRACT

Histone methylation is one of the important research contents of epigenetics. Methylation of histones is dynamically regulated by histone methylase and histone demethylase. Histone lysine (K) demethylase 5A (KDM5A) is an important member in the histone demethylase family, which can specifically remove the dimethyl and trimethyl from the 4th lysine of histone H3 (H3K4me2/3), thus mediating gene silencing and regulating cell function. KDM5A can directly or indirectly maintain tumor cell dryness, inhibit cell metabolism and differentiation, promote tumor cell proliferation, metastasis and drug resistance, so it is closely related to the occurrence, development and drug resistance of various tumors. KDM5A may become a new potential target for the diagnosis and treatment of tumors.