Research advances in gamma-glutamyl transferase promoting the development of cancers / 肿瘤

ABSTRACT

Gamma-glutamyl transferase (GGT), a key enzyme in the metabolism of glutathione (GSH), is widely distributed in various tissues and organs of human body, and is involved in the processes of cellular redox regulation, detoxification and ferroptosis. GGT expression is abnormally elevated in a variety of primary and metastatic tumors. High level of GGT is significantly associated with the high malignancy and poor prognosis of tumors. Recent studies have suggested that high activity of GGT in serum and exosomes can increase the incidence risk of various malignant tumors, and is associated with poor prognosis, suggesting that GGT may be a potential target for tumor treatment and a marker for tumor diagnosis and prognosis. The article reviews the research advances of GGT expression in tumor tissues and peripheral blood, and its association with the occurrence and development of malignant tumors, as well as its clinical significance and regulatory mechanisms.