Role of oxidative stress in tumor glucose metabolism / 肿瘤

ABSTRACT

Oxidative stress in tumor microenvironment is mainly derived from tumor epithelial cells, which is widely distributed in tumor tissues. Oxidative stress in tumor cells is mainly produced by the accumulation of reactive oxygen species (ROS). Low concentrations of ROS can activate the host cells in tumor microenvironment, and promote the glucose metabolism of cancers by inducing autophagy of mitochondria, changing key enzymes and genomes of glucose metabolism, and activating signaling pathways, so as to maintain the high energy requirement of tumors. High concentrations of ROS can inhibit the occurrence and development of tumors by inducing apoptosis of tumor cells. In recent years, whether anti-oxidant or pro-oxidant can fight against cancer has become a hot topic in cancer therapy. This review focuses on the role of oxidative stress in glucose metabolism of cancer and on the relationship between oxidation-antioxidation balance and tumor therapy, in order to provide new ideas for tumor targeting therapy.