Analysis of incidence characteristics of gastric cancer in Shanghai from 2003 to 2012 / 肿瘤

ABSTRACT

Objective: To analyze the incidence characteristics of gastric cancer in Shanghai from 2003 to 2012, and to compare them with the international data. Methods: The data of gastric cancer cases diagnosed between 2003 and 2012 were collected from Shanghai Cancer Registry. The international data of cancer incidence were sourced from GLOBOCAN 2012 database of WHO International Agency for Research on Cancer (IARC) and the Surveillance, Epidemiology and End Result (SEER) 18 database of National Cancer Institute (NCI). The incidence indicators of gastric cancer in Shanghai were calculated, including the average annual incidence, average age, constituent ratio, crude incidence, age-specific incidence and age-standardized incidence. Pearson χ2 test was applied to compare the proportions of cases with detailed pathology, histological type and diagnostic stage. Cochran χ2 test was used to compare the age-standardized incidence among the different diagnosis time or areas. Results: From 2003 to 2012, 57 812 new cases of gastric cancer were diagnosed in Shanghai, with an average of 5 781 cases per year, accounting for 10.89% among total new cancer cases; the incidence of gastric cancer ranked third in all cancers in Shanghai, with a crude incidence rate of 41.88 per 100 000 and an age-standardized incidence rate of 19.92 per 100 000. From 2008 to 2012, 29 373 new cases of gastric cancer were diagnosed in Shanghai, with an average of 5 875 cases per year, accounting for 10.19% among total new cancer cases; the median age was 69 years old and the mean age was 67.70 years old, the age-standardized incidence rate was 18.64 per 100 000. From 2003 to 2007, 28 439 new cases of gastric cancer were diagnosed in Shanghai, with an average of 5 688 cases per year, accounting for 11.74% among total new cancer cases; the median age was 70 years old and the mean age was 66.93 years old, the age-standardized incidence rate was 21.40 per 100 0000. The age-standardized incidence from 2008 to 2012 was significantly lower than that from 2003 to 2007 (P < 0.001). The standardized incidence of gastric cancer in Shanghai from 2008 to 2012 was higher than the average levels in the world (12.1 per 100 000) and the developed counties (10.6 per 100 000), and lower than the average levels in Eastern Asia (24.2 per 100 000) and China (22.7 per 100 000). The age-specific incidence rate of gastric cancer from 2003 to 2007 and 2008 to 2012 increased with age, and reached the peak at the age of 80-84. Compared with that in 2003-2007, the proportion of cases with gastric cancer at stage , definite clinical stage, detailed pathological type, and the highest basis for pathological diagnosis were significantly increased in 2008-2012 (all P < 0.001). Conclusion: Compared with 2003-2007, the incidence of gastric cancer in Shanghai was decreased from 2008 to 2012. The incidence of gastric cancer in Shanghai is still high, its age-standardized rate is lower than the average level in China and higher than that in the world.