Methods to improve the treatment of antitumor angiogenesis / 肿瘤

ABSTRACT

Abnormal vessel and function are hallmarks of cancer, and they contribute to cancer progression and migration. Angiogenesis has become an attractive target for drug therapy, and several regulatory and signaling molecules governing angiogenesis are of interest. Angiogenesis inhibitors, intending to block tumor's blood supply and provide survival benefits for cancer patients, may fuel tumor progression and treatment resistance. Actionable strategies to improve clinical efficacy of angiogenesis inhibitors include vascular mimicry regulation, tumor vessel normalization, seeking predictive factors, multi-targeted drugs development and combinational therapeutics. Moreover, strategies aiming at alleviating tumor hypoxia while improving perfusion may enhance the outcome of antiangiogenic therapy. Angiogenesis inhibitors offer an avenue for the development of cancer therapy.