Progress on blocking CD47 expression for tumor sensitization and normal tissue protection in radiotherapy / 肿瘤

ABSTRACT

Radiation therapy plays an important role in the treatment of carcinoma. Though radiation can kill tumor cells, the radioresistance of tumor cells and the side effects of radiotherapy are still problems to be solved urgently in the treatment of clinical tumors. How to enhance radiosensitivity and radioprotection is a research hotspot and difficult problem for radiologists. In recent years, it has been found that CD47, as a member of the transmembrane Ig superfamily on the cell surface and an extracellular ligand of signal-regulatory protein α (SIRPα), regulates tumorigenesis and repair function of normal tissues after radiation injury. Blocking the expression of CD47 has been found to confer radioprotection of normal tissues while enhancing tumor radiosensitivity. This paper puts forward that CD47 can be regarded as a target of radiosensitization for improving the tolerance of normal tissues to radiotherapy while enhancing the radiosensitivity of tumor tissues, so as to improve the curative effect of tumor radiotherapy.