Progress in nanoscale RNA delivery systems for the treatment of ovarian cancer / 肿瘤

ABSTRACT

For the moment, surgery and chemotherapy are the first-line treatment regimens of ovarian cancer, but the number of patients with chemotherapy resistance is increasing. Although molecular targeted therapy and immunotherapy have achieved some curative effects, the five-year overall survival rate of ovarian cancer patients has not been significantly improved. RNA interference (RNAi) is a posttranscriptional regulation technology which can silence the diseasecausing genes. Therefore, the gene therapy based on RNAi may be a new way to treat ovarian cancer. The non-viral nanoscale RNA delivery system has the advantages of low toxicity and high nucleic acid load. The nano-carrier materials mainly include polymers, lipids, mesoporous silicon and natural nanomaterials, etc. In recent years, the non-viral nanoscale RNA systems have obtained many favorable effects in the feld of ovarian cancer. This article reviews the current studies of nanoscale RNA systems, and introduces the application of nanoscale RNA systems in the feld of ovarian cancer.