Progress in the clinical significance and correlation of HER2 and FOXM1 in colorectal cancer / 肿瘤

ABSTRACT

The proliferation, progression and metastasis of colorectal cancer is a pathological process involving many factors. Human epidermal growth factor receptor 2 (HER2) and forkhead box M1 (FOXM1) are two oncogenes, and their encoded proteins play important roles in cell metabolism, proliferation, apoptosis, migration and invasion processes. FOXM1 may be a downstream effector regulated by HER2. Both of HER2 and FOXM1 are highly expressed in colorectal cancer, and correlated with clinicopathological parameters and prognosis. Therefore, HER2 and FOXM1 maybe have important reference value in the diagnosis, treatment and prognosis of colorectal cancer, and may be new therapeutic targets for colorectal cancer. This paper reviews the mechanisms of HER2 and FOXM1 action in colorectal cancer, the clinical significance of their expressions, and the correlation between the two proteins.