Research progress in miR-138 in tumors / 肿瘤

ABSTRACT

microRNA (miRNA, miR) has attracted great interest in recent years. miR-138 is closely related to the occurrence, development and prognosis of different kinds of malignant tumors.Present studies have shown that miR-138 is frequently down-regulated in tumor cells and tissues. Down-regulation expression of miR-138 can promote the proliferation, invasion and metastasis in a variety of malignant tumor cells. Up-regulation expression of miR-138 may play a crucial role in tumor suppression, and enhance sensitivity of tumor cells to radiotherapy and chemotherapy. Therefore, miR-138 can be considered as a biomarker of tumor prognosis, and also one of the tumor therapeutic targets.