Inhibiting effect of Duffy antigen receptor for chemokines on growth of lung adenocarcinoma A549 xenografts in nude mice and its possible mechanism / 肿瘤

ABSTRACT

Objective: To investigate the effects of local injection of Duffy antigen receptor for chemokines (DARC) protein on the growth of lung adenocarcinoma A549 xenografts in nude mice and the angiogenesis in xenograft tumor tissues. Methods: The lung cancer xenograft model was established by using lung adenocarcinoma A549 cells. After xenograft formation, the different doses (l, 10 and 100 ng) of DARC protein were injected into the xenografts as the low, medium and high dose groups, respectively; while 0.9% sodium chloride solution (100