Progress in abnormal metabolism of glutamine in cancer / 肿瘤

ABSTRACT

Metabolic abnormality has become an important feature of cancer cells, and the abnormal metabolism of glutamine is a vital part of it. Glutamine metabolic limits have been verified to be effective in inhibiting the growth of cancer cells. Glutamine canpro videe n ergy fo r r apidlygr o wi n g can cercells an d provide raw materials for various biological macromolecules such as amino acids, proteins, lipids and nucleotides. Multiple factors including Myc, p53, rat sarcoma (RAS), Rho GTPase and hypoxia inducible factor (HIF) are involved in the regulation of glutamine metabolism in cancer cells. The way to target abnormal metabolism of glutamine can be a potential strategy for the treatment of cancer.