Expression of ZKSCAN3 in breast cancer tissues and its significance / 肿瘤
Tumor
;
(12): 960-966, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-848490
ABSTRACT
Objective:
To investigate the expression of zinc finger with KRAB and SCAN domains 3 (ZKSCAN3) in breast cancer tissues and its clinical significance.Methods:
The expression of ZKSCAN3 in 120 specimens of human breast cancer tissues and 60 specimens of adjacent para-cancerous tissues was detected by immunohistochemistry, and its correlation with clinicopathological parameters and overall survival was analyzed. The real-time fluorescent quantitative PCR and Western blotting were used to further detect the expressions of ZKSCAN3 mRNA and protein in breast cancer tissues and the adjacent para-cancerous tissues.Results:
The positive expression rate of ZKSCAN3 protein in breast cancer tissues [74% (89/120)] was higher than that in the adjacent para-cancerous tissues [37% (22/60)] (P < 0.001). The expression of ZKSCAN3 protein was correlated with tumor size, lymph node metastasis, tumor differentiation and clinical stage of breast cancer (all P < 0.05). The overall survival rate of patient with ZKSCAN3-positive breast cancer was significantly lower than that of patient with ZKSCAN3-negative breast cancer (P = 0.040). The expression levels of ZKSCAN3 mRNA and protein in breast cancer tissues were higher than those in the adjacent para-cancerous tissues (both P < 0.01).Conclusion:
ZKSCAN 3 is associated with the occurrence, progression and metastasis of breast cancer, so it may be an oncogene of breast cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Tumor
Year:
2017
Type:
Article
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