Association between MTHFR C677T polymorphism and susceptibility of 5-FU chemotherapy regimens in the treatment of gastrointestinal cancer: A Meta-analysis / 肿瘤

ABSTRACT

Objective: To systematically evaluate the association between methylenetetrahydrofolatereductase (MTHFR ) C677T gene polymorphism andthe sensitivity of 5-fluorouracil (5-FU) chemotherapy regimens in thetreatment of gastrointestinal cancer.Methods: Such databases as PubMed, EBSCO, Web of Science,Cochrane Library, Chinese BioMedical Literature Database (CBM),China National Knowledge Infrastructure (CNKI), VIP and WanFangData were systematically searched to collect studies on theassociation between MTHFR C677T gene polymorphism and thesensitivity of 5-FU chemotherapy regimens in the treatment ofgastrointestinal cancer published from each database establishingtime to December 2016. All of subjects were selected by tworeviewers, and the data were extracted according to the inclusionand exclusion criteria. Meta- analysis was performed using RevMan5.3 statistical software, the sensitivity analysis and publication biasassessment were performed using STATA 12.0 statistical software.Resul t s A total of 11 studies involving 1 267 patients withgastrointestinal cancer were included. The sensitivity of patients withMTHFR 677T allele to 5-FU chemotherapy regimens was significantlyhigher than that of patients with C allele [odds ratio (OR ) = 5.31,95% confidence interval (CI ) 3.23-8.73, P < 0.001]. The sensitivity ofpatients carried TT allele to chemotherapy regimens was significantlyhigher than that of patients carried CC allele (OR = 4.87, 95% CI2.18-10.86, P < 0.001). The sensitivity of patients with TT + TCgenotype to chemotherapy regimens was significantly higher thanthat of patients with CC genotype (OR = 0.52, 95% CI 0.33-0.84, P =0.007). TT genotype patients were significantly more sensitive tochemotherapy as compared with CC + TC genotype patients (OR =4.39, 95% CI 2.07-9.32, P < 0.001).Co n c l u s i o n The pol ymorphi sm of MTHFR C677T gene ingastrointestinal cancer patients is significantly correlated with thesensitivity of 5-FU chemotherapy regimen.