Histone methyltransferase SMYD3 and tumor / 肿瘤

ABSTRACT

Histone methyltransferase SMYD3 (SET and MYND domain containing3) plays an important role in tumor epigenetics. Its high expressionin many cancer cells can promote the development and progressionof tumor by regulating several cellular biological functions such asproliferation, apoptosis, invasion and metastasis. Previous studieshave indicated that SMYD3 mainly modulate the methylation of lysineH3K4 to regulate the expression of certain genes. Recent researcheshave shown that SMYD3 can also interact with other histones andcytoplasmic proteins to regulate the expression of tumor-relatedgenes, thereby to promote the development of tumor. This reviewaims to introduce the structure, upstream regulatory pathwayand synergistic molecules of SMYD3, as well as to summarize itsregulation mechanisms, expression and inhibitors in tumor.