Methylation of gstp 1 gene promoter and the risk of prostate cancer: A meta-Analysis / 肿瘤

ABSTRACT

Objective: To evaluate the association of glutathione S-Transferase P1 (GSTP 1) gene promoter methylation with the risk of prostate cancer. Methods: A computer-based online search was performed in PubMed, Embase, Cochrane Library, ISI Web of Science and China National Knowledge Infrastructure (CNKI) databases. According to the inclusion and exclusion criteria, the literatures about GSTP 1 gene promoter methylation and the risk of prostate cancer were selected. The difference in the incidence rate of GSTP 1 promoter methylation was compared between the prostate cancer tissues and the non-prostate cancer tissues, as well as in the blood or urine between the prostate cancer patients and the non-prostate cancer patients. The outcome measurements were odds ratio (OR ) with 95% confidence interval (95% CI ) for the association between the GSTP 1 gene promoter methylation and the risk of prostate cancer. The Meta-Analysis was performed using Stata 12.0 software. Results: A total of 19 studies including 1 889 samples were included in this Meta-Analysis. The result of the Meta-Analysis showed that GSTP 1 gene promoter methylation increased the risk of prostate cancer by 23.49 times [OR 23.49 (95% CI 13.14-42.01), P < 0.001]. Conclusion: GSTP 1 gene promoter methylation may increase the risk of prostate cancer.