The expressions of CD151 and MMP-7 in lung adenocarcinoma tissues and their clinical significance / 肿瘤
Tumor
;
(12): 624-632, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-848531
ABSTRACT
Objective:
To observe the expressions of CD151 and matrix metalloproteinase-7 (MMP-7) in lung adenocarcinoma tissues and their clinical significance.Methods:
The expressions of CD151 and MMP-7 in 149 lung adenocarcinoma tissue samples and 40 adjacent normal tissue samples were detected by immunohistochemistry. The relationship between the expressions of CD151 and MMP-7 and their correlation with the clinicopathological data were analyzed. The disease-free survival (DFS)-related factors were examined.Results:
The positive expression rates of CD151 and MMP-7 in lung adenocarcinoma tissues were higher than those in adjacent normal tissues (both P < 0.05). The CD151 expression was associated with smoking, lymph node metastases and TNM stage (all P < 0.05). The MMP-7 expression was associated with lymph node metastases and TNM stage (both P < 0.05). There was a positive correlation between CD151 and MMP-7 expressions in lung adenocarcinoma tissues (r = 0.322, P < 0.05). The DFS of patients with positive expression of CD151 was shorter than that of the patients with negative expression of CD151 (P = 0.005). The DFS of patients with coexpression of CD151 and MMP-7 was shorter than that of the patients with negative expressions of CD151 and MMP-7 (P = 0.004). CD151 was an independent DFS-related factor in patients with lung adenocarcinoma (P < 0.05).Conclusion:
The positive expression rates of CD151 and MMP-7 are high in lung adenocarcinoma tissues. The DFS of patients with positive expression of CD151 is relatively short.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Tumor
Year:
2017
Type:
Article
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