Progress in the association between protein subcellular localization and tumor progression / 肿瘤

ABSTRACT

The change of subcellular localization of tumor-related proteins affects the protein structure and biological function, which is closely related to tumorigenesis, tumor progression and prognosis. Aberrant phosphorylation, acetylation and ubiquitination lead to the subcellular localization change of tumor-related proteins, subsequently disrupt the down-stream target gene expression and the related cell signal pathways, which is an important factor for tumorigenesis. The anti-cancer drugs targeting post-Translational protein modification can reverse the abnormal subcellular localization of tumor-related proteins, so as to suppress the migration of tumor cells, and induce the apoptosis of tumor cells. This paper reviews the recent studies regarding the effects of phosphorylation, acetylation and ubiquitination on subcellular localization of tumor-related proteins such as p53, p27 and forkhead box protein O1 (FOXO1), and summarizes the molecular mechanisms of subcellular localization change induced by anti-cancer drugs, furthermore discusses the great significance of protein subcellular localization in clinical tumor diagnosis and the pridiction of prognosis and the drug effect.